GMP-Ready Pilot Freeze Dryers for Fill-Finish Integration

The Hull LyoConstellation™ S10/S20/S30 Pilot Lyophilizers deliver advanced pilot-scale lyophilization for pharmaceutical development, clinical production, and aseptic manufacturing. Designed to integrate into fill-finish workflows and cleanroom environments seamlessly, these GMP-compliant freeze dryers support cycle development, scale-up, and full production with precision and reliability.

Built on SP Scientific’s freeze-drying innovation, the LyoConstellation™ range provides unmatched flexibility, validation support, and Process Analytical Technology (PAT) integration — ensuring quality, compliance, and scalable technology transfer.

Advanced Pilot Lyophilization for Pharma & Biotech

The LyoConstellation™ S10, S20, and S30 models are engineered for:

• Cycle development and optimization

• Stability studies and pilot batch production

• Clinical trial manufacturing

• Scale-up to full aseptic production

These pilot lyophilizers are fully GMP-ready and built to meet the strict regulatory requirements of pharmaceutical and biotechnology manufacturing environments.

Key Features & Benefits

✔ Designed for End-to-End Lyophilization

Supports development through full production scale, ensuring smooth process transfer and reduced scale-up risk.

✔ Integrated PAT & Line of Sight™ Technology

Compatible with SP’s advanced Line of Sight™ Lyophilization suite for real-time process monitoring and control.

✔ Simplified Validation & Compliance

• Standard validation ports in the chamber and condenser

• Comprehensive documentation package

• Regulatory-ready support

✔ Accurate Endpoint Detection

• Pirani gauge (standard)

• Capacitance manometer (standard)
  Ensures precise determination of primary and secondary drying phases.

✔ High-Performance Engineering

• Accommodates vials up to 30 mL

• Holds 100 mTorr at +40°C shelf temperature (fully loaded)

• Built for demanding pharmaceutical freeze-drying applications

✔ Full CIP & SIP Capability

• Steam-In-Place (SIP)

• Clean-In-Place (CIP)

• Manual/H₂O₂ options available

✔ Isolator Ready

• Auto-locking doors

• Designed for aseptic integration

Line of Sight™ Lyophilization & PAT Tools

The LyoConstellation™ pilot freeze-dryers are compatible with SP Scientific’s advanced Process Analytical Technologies (PAT) to optimize freeze-drying cycle development and scale-up:

• LyoFlux® TDLAS – Accurate water vapor mass flow measurement during freeze-drying

• SMART™ Freeze Dryer Technology – Real-time feedback on resistance, heat flow, and mass transfer

• TEMPRIS® Wireless Sensors – Advanced wireless temperature monitoring for high-value products

• ControLyo® Nucleation Technology – Precision freezing point control for consistent product structure

These technologies support simplified tech transfer, improved product quality, and reduced cycle development time.

Applications

The Hull LyoConstellation™ pilot lyophilizers are ideal for:

• Vaccines

• Antibody Drug Conjugates (ADCs)

• Highly potent compounds

• Biologics

• Sterile injectable pharmaceuticals

Why Choose Hull LyoConstellation™ Pilot Freeze Dryers?

• GMP-compliant pilot lyophilizer solutions

• Seamless fill-finish integration

• Advanced PAT-enabled freeze-drying control

• Scalable from development to production

• Designed for pharmaceutical cleanroom environments

If you’re scaling lyophilization from development to clinical and commercial production, the Hull LyoConstellation™ S10/S20/S30 delivers precision, compliance, and performance in one integrated system.